A wrong-way driver crashed head-on into another vehicle on the Long Island Expressway in Holtsville, killing both drivers.

The driver of a 2013 Chevrolet Silverado crashed head-on into a 2005 Acura in the middle lane westbound at exit 61 just before 12:45 a.m. Thursday.

The wrong-way driver, 61-year-old Thomas Raimondo, and the other driver, 32-year-old Jose Ferreira, were both killed.

There were no passengers in the vehicles and no one else was injured.

A physician assistant from the Suffolk County Medical Examiner’s Office declared both dead at the scene.

Westbound lanes remained closed for the investigation at exit 62.

Detectives are asking anyone with information on the crash to call the Sixth Squad at 631-854-8652.